ROMA Index Calculator
Calculate the Risk of Ovarian Malignancy Algorithm using HE4, CA 125 and menopausal status in women with an adnexal mass.
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ROMA Calculation Formula
ln represents the natural logarithm. The ROMA algorithm should be used with the assay methodology for which the equations have been validated.
ROMA Risk Interpretation
| Menopausal Status | ROMA | Category |
|---|---|---|
| Premenopausal | Less than 11.4% | Low risk |
| Premenopausal | 11.4% or higher | High risk |
| Postmenopausal | Less than 29.9% | Low risk |
| Postmenopausal | 29.9% or higher | High risk |
What is the ROMA Index?
The Risk of Ovarian Malignancy Algorithm, or ROMA, combines serum HE4 and CA 125 concentrations with menopausal status to estimate the likelihood of epithelial ovarian malignancy in women presenting with an adnexal mass.
ROMA provides a risk stratification result rather than establishing a diagnosis of ovarian cancer.
The result should be considered together with pelvic imaging, clinical findings and appropriate specialist assessment.
Important Laboratory Consideration
ROMA is an assay-dependent algorithm. The equations and clinical cutoffs used by different commercial ROMA methodologies may not be interchangeable.
This calculator uses the commonly published Elecsys HE4 and Elecsys CA 125 II methodology and its associated ROMA equations.
HE4 and CA 125 results should therefore be interpreted using the method-specific instructions and validated laboratory procedure applicable to the assay being used.
ROMA Index Calculator - Frequently Asked Questions
What does ROMA stand for?
ROMA stands for Risk of Ovarian Malignancy Algorithm. It combines HE4, CA 125 and menopausal status.
Which laboratory tests are required?
ROMA requires serum HE4 and CA 125 measurements, together with menopausal status.
Why are there two ROMA formulas?
The validated predictive-index coefficients differ between premenopausal and postmenopausal women.
Is a high ROMA diagnostic of ovarian cancer?
No. A high ROMA indicates a higher estimated likelihood within the validated risk-stratification method. It does not independently diagnose ovarian cancer.
Can ROMA replace ultrasound?
No. ROMA should be interpreted together with pelvic imaging and clinical assessment.
Is ROMA a screening test?
ROMA is intended for risk assessment in women with an adnexal or pelvic mass and is not a general population screening test for ovarian cancer.
Medical Disclaimer: This calculator is provided for educational and clinical reference purposes. ROMA is a risk-stratification algorithm and does not independently diagnose ovarian cancer. Results are dependent on the assay methodology and validated calculation method. This calculator uses the published Elecsys HE4 and CA 125 II ROMA methodology. Always verify results against the laboratory's current assay instructions and interpret them together with clinical findings and imaging. This tool does not replace professional medical evaluation.
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